You can get 80% of the way with rules of thumb. One rule of thumb is to turn off or reduce the bid on your worst keywords, especially if they are above 100% (and you are in KU, above 70% if you are not). This will increase efficiency, but it also scales down your discoverability.
Read-thru is a huge factor in calculating overall ROI. As a rule of thumb, if you have at least 3 books in the series, and the read-through is above 70%, you can double your ACOS limits and still break even, especially if you're in KU.
If you have data from before you started using AA and after, you might be able to compare the befores and afters and get a rough idea of the ROI of the change. In other words, if (all else being equal) you spent $150 to gain $300 in ebook sales at 70% earning (overall increase from your baseline, that's the key, not what AA says), which nets you $210, you made about $60. Even if AA says your ACOS was (say) 110%, if your overall ebook sales and net profit increased, it's worth it. Some of it will be from read-through, and some will be echo effects of greater visibility.