I'm still keeping my stacks of paperback murder mysteries for that mythical cottage at the shore or cabin in the hills that I will never own. Mysteries make excellent reading for bored house guests, and Agatha Christie is a master of prose. This isn't the house I expect to die in, so there will be a Great Culling in the future.
Lawyer's bookcases, with their glass fronts, take care of any dusting issues; mine came from the home of my grandfather the lawyer and unlike what are sold in stores new are infinitely adaptable since each shelf is actually a separate unit. An old family music cabinet with a glass front keeps copies of my own novels dust free.
In our family we do have multiple houses stuffed with books. Not only novels--although some are not easily discarded because they're rare or autographed--but also fascinating works on history, art, geography, linguistics, religion, archeology, and many more topics. What to do with them? They'll have to move on someday, as will we. A different version of a Great Culling awaits.